| File Extension | File Type |
| EXPLOSION | Unknown Apple II File (found on Golden Orchard Apple II CD Rom) |
| EXPORT | CATIA Export File (Dassault Systèmes) |
| EXR | OpenEXR Bitmap (Lucas Digital Ltd. LLC.) |
| EXS | Emagic EXS-24 Instrument Files (Apple Inc.) |
| EXS | VideoNet Director Video File (inLighten) |
| EXT | Extinction Corrected Photometry |
| EXT | WS-FTP ASCII Binary Transfer File |
| EXT | E-mail Text Attachment |
| EXT | Unknown Apple II File (found on Golden Orchard Apple II CD Rom) |
| EXT | Norton Commander Extension File |
| EXTBASE | Associate This Extension Base (Spearit) |
| EXTRA | Unknown Apple II File (found on Golden Orchard Apple II CD Rom) |
| EXTRA2 | Unknown Apple II File (found on Golden Orchard Apple II CD Rom) |
| EXU | Euphoria Source Code (Rapid Deployment Software) |
| EXW | Euphoria Source Code (Rapid Deployment Software) |
| EXX | IBM LinkWay MsgPut Intermediate File |
| EXY | Orchida Embroidery System (Orchida Soft) |
| EX^ | Norton Live Update File |
| EX_ | Compressed EXE File |
| EYA | eYaViewer Graphic (ESRI China (Beijing)) |
| EYB | Encarta Encyclopedia Yearbook and Web Links Update File (Microsoft Corporation) |
| EYE | ETI Camcorder Pro Video File (Eyemail Technology, Inc.) |
| EYE | Eyeris Encoded Audio/Video File (Eyewonder, Inc.) |
| EYE | Unknown Apple II File (found on Golden Orchard Apple II CD Rom) |
| EYE | Renderize Project |
| EYE | CubicEye Cube |
| EYE | Eyemail Video (Eyemail Technology Inc (ETI)) |
| EYE | Glass Eye File |
| EYP | EasyFP |
| EZ2 | EZPix Secure Photo Album Photo Package (Electronic Zombie Corp.) |
| EZ3 | EZPix Secure Photo Album Photo Package (Electronic Zombie Corp.) |
| EZB | EasyBoot Image File (EZB Systems, Inc.) |
| EZB | EasyBookkeeper Native Format File (e-press Corp) |
| EZC | EZClaim Memorized Claim File (EZClaim) |
| EZC | EZScreen Screen Saver Editor |
| EZC | EZGUI Designer Control Definition (Christopher R. Boss) |
| EZHEX | Harmony Advanced Universal Remote Saved Configuration File (Logitech) |
| EZL | EasyLog Well Log Record (EasySolve Software LLC) |
| EZM | Text File |
| EZN | EZClaim Memorized Note File (EZClaim) |
| EZP | Edify Electronic Workforce Backup Utility Compressed Slips File |
| EZP | EDIUS Project File (Thomson S.A.) |
| EZP | EasyPlot Saved Data (Spiral Software) |
| EZP | EZ-Pix Image (Xequte Software) |
| EZS | EZ-R Stats for Windows Batch Submit File (EZ-R Stats, LLC) |
| EZS | Sunburst Technology Easy Sheet Document |
| EZT | Sunburst Technology Easy Sheet Template |
| EZX | EZ-Forms (EZ-Forms Company) |
| EZX | WHAP File |
| E_E | Eru file |
